概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EPSRPSPQPKPRTP
    • 氨基酸139 to 152

技术指标

Our Abpromise guarantee covers the use of ab23136 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Beckwith Wiedemann syndrome chromosome region 1 candidate protein C
    • Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein
    • BRW 1C
    • BRW1C
    • BWR 1C
    • BWR1C
    • HLDA 2
    • HLDA2
    • Imprinted in placenta and liver
    • Imprinted in placenta and liver protein
    • IPL
    • p17 Beckwith Wiedemann region 1C
    • p17 BWR1C
    • p17-Beckwith-Wiedemann region 1 C
    • p17-BWR1C
    • PHLA2_HUMAN
    • PHLDA 2
    • phlda2
    • Pleckstrin homology like domain family A member 2
    • Pleckstrin homology-like domain family A member 2
    • TSSC 3
    • Tumor suppressing STF cDNA 3 protein
    • Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein
    • Tumor suppressing subchromosomal transferable fragment cDNA 3
    • Tumor suppressing subtransferable candidate 3
    • Tumor supressing STF cDNA 3
    • Tumor-suppressing STF cDNA 3 protein
    • Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
    see all
  • 功能Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
  • 组织特异性Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both fetus and trophoblast. The majority of hydatidiform moles are associated with an excess of paternal to maternal genomes and are likely to result from the abnormal expression of imprinted genes (at protein level). Expressed at low levels in adult liver and lung, and fetal liver. Expressed in adult brain and neuroblastoma, medullablastoma and glioblastoma cell lines.
  • 序列相似性Belongs to the PHLDA2 family.
    Contains 1 PH domain.
  • 结构域The PH domain binds phosphoinositides with a broad specificity. It may compete with the PH domain of some other proteins, thereby interfering with their binding to phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-triphosphate (PIP3).
  • 细胞定位Cytoplasm. Membrane.
  • Information by UniProt

Human TSSC3 peptide (ab23136)参考文献

ab23136 has not yet been referenced specifically in any publications.

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