概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab101401 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TRP1 antibody (ab73873)

  • 纯度70 - 90% by HPLC.

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • 5
    • 5,6 dihydroxyindole 2 carboxylic acid oxidase
    • 6-dihydroxyindole-2-carboxylic acid oxidase
    • b-PROTEIN
    • CAS2
    • Catalase B
    • CATB
    • DHICA oxidase
    • Glycoprotein 75
    • GP75
    • Melanoma antigen gp75
    • OCA3
    • TRP
    • TRP-1
    • TRP1
    • Tyrosinase related protein 1
    • Tyrosinase-related protein 1
    • TYRP
    • TYRP1
    • TYRP1_HUMAN
    • TYRRP
    see all
  • 功能Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized.
  • 组织特异性Pigment cells.
  • 通路Pigment biosynthesis; melanin biosynthesis.
  • 疾病相关Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3) [MIM:203290]; also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
  • 序列相似性Belongs to the tyrosinase family.
  • 细胞定位Melanosome membrane.
  • Information by UniProt

Human TRP1 peptide (ab101401)参考文献

ab101401 has not yet been referenced specifically in any publications.

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