概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-LNSLNQAVVSKLA
    • 氨基酸
      421 to 443

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23046 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TRIP15 antibody (ab4537)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • ALIEN
    • Alien Drosophila himolog of
    • Alien homolog
    • COP 9
    • COP9
    • COP9 constitutive photomorphogenic homolog subunit 2
    • COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)
    • COP9 signalosome complex subunit 2
    • COPS 2
    • Cops2
    • CSN2
    • CSN2_HUMAN
    • JAB1 containing signalosome subunit 2
    • JAB1-containing signalosome subunit 2
    • SGN 2
    • SGN2
    • Signalosome subunit 2
    • Thyroid Hormone Receptor Interactor15
    • Thyroid Hormone Receptor Interactor 15
    • Thyroid receptor-interacting protein 15
    • TR-interacting protein 15
    • TRIP 15
    • TRIP-15
    • TRIP15
    see all
  • 功能
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • 序列相似性
    Belongs to the CSN2 family.
    Contains 1 PCI domain.
  • 翻译后修饰
    Phosphorylated by CK2 and PKD kinases.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

文献

ab23046 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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