概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EDLSFNTDENSGR
    • 氨基酸952 to 964

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23224 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TRIM37 antibody (ab13619)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • E3 ubiquitin protein ligase TRIM37
    • E3 ubiquitin-protein ligase TRIM37
    • KIAA0898
    • MUL
    • MUL protein
    • Mulibrey nanism gene
    • Mulibrey nanism protein
    • POB 1
    • POB1
    • RING B box coiled coil protein
    • TEF 3
    • TEF3
    • TRI37_HUMAN
    • TRIM 37
    • Trim37
    • Tripartite motif containing 37
    • Tripartite motif containing 37 protein
    • Tripartite motif containing protein 37
    • Tripartite motif-containing protein 37
    see all
  • 功能E3 ubiquitin-protein ligase.
  • 组织特异性Ubiquitous.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Defects in TRIM37 are the cause of mulibrey nanism (MUL) [MIM:253250]; also known as muscle-liver-brain-eye nanism. MUL is an autosomal recessive disorder that involves several tissues of mesodermal origin, implying a defect in a highly pleiotropic gene. Characteristic features include severe growth failure of prenatal onset and constrictive pericardium with consequent hepatomegaly. In addition, muscle hypotonia, J-shaped sella turcica, yellowish dots in the ocular fundi, typical dysmorphic features and hypoplasia of various endocrine glands causing hormonal deficiency are common.
  • 序列相似性Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 MATH domain.
    Contains 1 RING-type zinc finger.
  • 翻译后修饰Auto-ubiquitinated.
  • 细胞定位Cytoplasm > perinuclear region. Peroxisome. Found in vesicles of the peroxisome. Aggregates as aggresomes, a perinuclear region where certain misfolded or aggregated proteins are sequestered for proteasomal degradation.
  • Information by UniProt

Human TRIM37 peptide (ab23224)参考文献

ab23224 has not yet been referenced specifically in any publications.

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