概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      CRPKGGSGDTLAPQ
    • 氨基酸
      455 to 468

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22996 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TRIM11 antibody (ab4153)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • BIA 1
    • BIA1
    • E3 ubiquitin protein ligase TRIM11
    • E3 ubiquitin-protein ligase TRIM11
    • Protein BIA1
    • RING finger protein 92
    • RING type E3 ubiquitin transferase TRIM11
    • RNF 92
    • RNF92
    • TRI11_HUMAN
    • Trim 11
    • TRIM11
    • Tripartite motif containing 11
    • tripartite motif protein 11
    • Tripartite motif-containing protein 11
    see all
  • 功能
    E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle.
  • 组织特异性
    Ubiquitous.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Belongs to the TRIM/RBCC family.
    Contains 1 B box-type zinc finger.
    Contains 1 B30.2/SPRY domain.
    Contains 1 RING-type zinc finger.
  • 结构域
    The coiled-coil domain and the B30.2 domain are both necessary for interaction with HN and PAX6 (By similarity). They are also involved in MED15-binding.
    The B30.2 domain may be involved cellular protein quality control by promoting the degradation of insoluble ubiquitinated proteins.
  • 细胞定位
    Cytoplasm. Nucleus.
  • Information by UniProt

Human TRIM11 peptide (ab22996)参考文献

ab22996 has not yet been referenced specifically in any publications.

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