概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-RESQSYLVEDLERS
    • 氨基酸182 to 195

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技术指标

Our Abpromise guarantee covers the use of ab22875 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-TMS1 antibody (ab2236)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Apoptosis associated speck like protein containing a CARD
    • Apoptosis-associated speck-like protein containing a CARD
    • ASC
    • ASC_HUMAN
    • CARD 5
    • CARD5
    • Caspase recruitment domain containing protein 5
    • Caspase recruitment domain protein 5
    • Caspase recruitment domain-containing protein 5
    • hASC
    • MGC10332
    • PYCARD
    • PYD and CARD domain containing
    • PYD and CARD domain containing protein
    • PYD and CARD domain-containing protein
    • Target of methylation induced silencing 1
    • Target of methylation-induced silencing 1
    • TMS
    • TMS 1
    • TMS1
    see all
  • 功能Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
  • 组织特异性Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Detected in the leukemia cell lines HL-60 and U937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and Molt 4 lymphocytic leukemia cells.
  • 序列相似性Contains 1 CARD domain.
    Contains 1 DAPIN domain.
  • 结构域Interacts with CIAS1/PYPAF1 and PYDC1 via the DAPIN domain.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Cytoplasm. Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.
  • Information by UniProt

Human TMS1 peptide (ab22875)参考文献

ab22875 has not yet been referenced specifically in any publications.

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