概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列KETRNMVQRQFIA
    • 氨基酸223 to 235

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技术指标

Our Abpromise guarantee covers the use of ab39885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • 应用

    Western blot

    Blocking - Blocking peptide for Anti-TICAM2 antibody (ab17221)

  • 形式Liquid
  • 补充说明Stable for at least 1 year at -20°C.The ab39885 peptide blocks antibodies that recognise amino acids 223-235 of human TICAM-2.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • Putative NF-kappa-B-activating protein 502
    • TCAM2_HUMAN
    • TICAM-2
    • TICAM2
    • TIR containing adapter molecule 2
    • TIR domain containing adaptor protein
    • TIR domain-containing adapter molecule 2
    • TIRAP 3
    • TIRAP3
    • TIRAP3a short form
    • TIRP
    • Toll-like receptor adaptor protein 3
    • Toll/interleukin-1 receptor domain-containing protein
    • TRAM
    • TRIF-related adapter molecule
    see all
  • 功能Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.
  • 组织特异性Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas.
  • 序列相似性Contains 1 TIR domain.
  • 结构域The TIR domain mediates the interaction with TRAF6.
  • 翻译后修饰Phosphorylated by PKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation.
    Myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
  • 细胞定位Cytoplasm. Golgi apparatus. Cell membrane. Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane.
  • Information by UniProt

Human TICAM2 peptide (ab39885)参考文献

ab39885 has not yet been referenced specifically in any publications.

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