The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-TBL1 antibody (ab2243)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
F box like/WD repeat protein TBL1X
F-box-like/WD repeat-containing protein TBL1X
Transducin (beta) like 1
Transducin (beta) like 1 X linked
Transducin (beta) like 1X linked
Transducin beta like 1 X linked
Transducin beta like 1X
Transducin beta like 1X protein
Transducin beta like protein 1, X linked
Transducin beta-like protein 1X
Transducin-beta-like protein 1
功能F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.
序列相似性Belongs to the WD repeat EBI family. Contains 1 F-box-like domain. Contains 1 LisH domain. Contains 8 WD repeats.
结构域The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.