概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EEREKNWKEKKTTE
    • 氨基酸572 to 585

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技术指标

Our Abpromise guarantee covers the use of ab22913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SWAP70 antibody (ab2511)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • KIAA0640
    • 70kDa
    • AV235546
    • FLJ39540
    • HSPC321
    • SWA 70 protein
    • SWAP 70
    • SWAP switching B-cell complex 70kDa subunit
    • SWAP-70
    • SWAP70
    • Switch associated protein 70
    • Switch-associated protein 70
    • SWP70_HUMAN
    see all
  • 功能Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
  • 组织特异性Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).
  • 序列相似性Contains 1 PH domain.
  • 结构域The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.
  • 翻译后修饰Tyrosine-phosphorylated.
  • 细胞定位Cytoplasm. Cell membrane. Nucleus. Cell projection > lamellipodium. In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.
  • Information by UniProt

Human SWAP70 peptide (ab22913)参考文献

ab22913 has not yet been referenced specifically in any publications.

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