概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-DAFISENGWVEDY
    • 氨基酸
      291 to 303

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45460 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-STUB1 antibody (ab2482)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • Antigen NY CO 7
    • Antigen NY-CO-7
    • C terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70 interacting protein
    • Carboxy terminus of Hsp70-interacting protein
    • Carboxy terminus of Hsp70p interacting protein
    • CHIP
    • CHIP_HUMAN
    • CLL associated antigen KW 8
    • CLL-associated antigen KW-8
    • E3 ubiquitin protein ligase CHIP
    • E3 ubiquitin-protein ligase CHIP
    • Heat shock protein A binding protein 2 (c terminal)
    • HSPABP2
    • NY CO 7
    • PP1131
    • SDCCAG7
    • Serologically defined colon cancer antigen 7
    • STIP1 homology and U Box containing protein 1
    • STIP1 homology and U box containing protein 1 E3 ubiquitin protein ligase
    • STIP1 homology and U box-containing protein 1
    • STUB 1
    • STUB1
    • UBOX 1
    • UBOX1
    see all
  • 功能
    E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes, including Hsp70, Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4.
  • 组织特异性
    Highly expressed in skeletal muscle, heart, pancreas, brain and placenta. Detected in kidney, liver and lung.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 3 TPR repeats.
    Contains 1 U-box domain.
  • 结构域
    The TPR domain is essential for ubiquitination mediated by UBE2D1.
  • 翻译后修饰
    Phosphorylated upon DNA damage, probably by ATM or ATR.
    Auto-ubiquitinated; mediated by UBE2D1 and UBE2D2.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

文献

ab45460 has not yet been referenced specifically in any publications.

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