The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SSX2IP antibody (ab10256)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Afadin and alpha actinin binding protein
Afadin DIL domain interacting protein
Afadin DIL domain-interacting protein
Afadin- and alpha-actinin-binding protein
SSX 2 interacting protein
SSX2 interacting protein
Synovial sarcoma X breakpoint 2 interacting protein
功能Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin.
组织特异性Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.
结构域Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2.
细胞定位Cell junction > adherens junction. Nucleus. Not found at cell-matrix AJs.