The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-SORBS1 antibody (ab4551)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
CBL Associated Protein
SH3 domain protein 5
Sorbin and SH3 Domain Containing 1
Sorbin and SH3 domain-containing protein 1
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin-stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Detected in skeletal muscle (at protein level). Widely expressed with highest levels in heart and skeletal muscle.
Contains 3 SH3 domains. Contains 1 SoHo domain.
Cell junction > adherens junction. Cell membrane. Cytoplasm > cytoskeleton. Cell junction > focal adhesion. Colocalizes with actin stress fibers. Also detected at the plasma membrane and in neuronal intranuclear inclusions. Colocalized with PXN at focal adhesions during myogenic differentiation.