概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-PIREFLDQYDAPL
    • 氨基酸213 to 225

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22776 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SOCS3 antibody (ab723)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • ATOD4
    • CIS 3
    • CIS-3
    • CIS3
    • Cish3
    • Cytokine induced SH2 protein 3
    • Cytokine-inducible SH2 protein 3
    • E2a Pbx1 target gene in fibroblasts 10
    • EF 10
    • MGC71791
    • SOCS 3
    • SOCS-3
    • Socs3
    • SOCS3_HUMAN
    • SSI 3
    • SSI-3
    • SSI3
    • STAT induced STAT inhibitor 3
    • STAT-induced STAT inhibitor 3
    • Suppressor of cytokine signaling 3
    see all
  • 功能SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.
  • 组织特异性Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus.
  • 通路Protein modification; protein ubiquitination.
  • 疾病相关Note=There is some evidence that SOCS3 may be a susceptibility gene for atopic dermatitis linked to 17q25. SOCS3 messenger RNA is significantly more highly expressed in skin from patients with atopic dermatitis than in skin from healthy controls. Furthermore, a genetic association between atopic dermatitis and a haplotype in the SOCS3 gene has been found in two independent groups of patients.
  • 序列相似性Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • 结构域The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • 翻译后修饰Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1.
  • Information by UniProt

Human SOCS3 peptide (ab22776)参考文献

ab22776 has not yet been referenced specifically in any publications.

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