概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab39852 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SOCS1 antibody (ab37167)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • CISH 1
    • CISH1
    • Cytokine inducible SH2 protein 1
    • JAB
    • JAK binding protein
    • JAK-binding protein
    • Janus kinase binding protein
    • SOCS 1
    • SOCS-1
    • Socs1
    • SOCS1_HUMAN
    • SSI 1
    • SSI-1
    • SSI1
    • STAT induced STAT inhibitor 1
    • STAT-induced STAT inhibitor 1
    • Suppressor of cytokine signaling 1
    • Supressor of cytokine signalling 1
    • TEC interacting protein 3
    • Tec-interacting protein 3
    • TIP 3
    • TIP-3
    • TIP3
    see all
  • 功能
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
  • 组织特异性
    Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
  • 通路
    Protein modification; protein ubiquitination.
  • 序列相似性
    Contains 1 SH2 domain.
    Contains 1 SOCS box domain.
  • 结构域
    The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition.
    The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box.
  • Information by UniProt

Human SOCS1 peptide (ab39852)参考文献

ab39852 has not yet been referenced specifically in any publications.

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