概述

  • 产品名称人SLC22A1肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列LSCVDPLASLATNRSHLPLGPCQDGWVYDTPGSSIVTEFNLVCADSWKLD

相关产品

技术指标

Our Abpromise guarantee covers the use of ab111655 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SLC22A1 antibody (ab55916)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • hOCT1
    • OCT1
    • oct1_cds
    • Organic cation transporter 1
    • S22A1_HUMAN
    • Slc22a1
    • solute carrier family 22 (organic cation transporter), member 1
    • Solute carrier family 22 member 1
    see all
  • 功能Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.
  • 组织特异性Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.
  • 序列相似性Belongs to the major facilitator superfamily. Organic cation transporter family.
  • 翻译后修饰Phosphorylated.
  • 细胞定位Basolateral cell membrane.
  • Information by UniProt

Human SLC22A1 peptide (ab111655)参考文献

ab111655 has not yet been referenced specifically in any publications.

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