概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab26153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • CDK2/Cyclin A associated protein p45
    • Cyclin A/CDK2 associated protein p45
    • Cyclin-A/CDK2-associated protein p45
    • F box protein Skp2
    • F box/LRR repeat protein 1
    • F-box protein Skp2
    • F-box/LRR-repeat protein 1
    • FBL 1
    • FBL1
    • FBXL 1
    • FBXL1
    • FLB 1
    • FLB1
    • MGC1366
    • p45
    • p45skp2
    • S phase kinase associated protein 2
    • S phase kinase associated protein 2 (p45)
    • S-phase kinase-associated protein 2
    • S-phase kinase-associated protein 2 E3 ubiquitin protein ligase
    • SKP 2
    • Skp2
    • SKP2_HUMAN
    see all
  • 功能Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, MLL, CDK9, RAG2, FOXO1A, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 1 F-box domain.
    Contains 9 LRR (leucine-rich) repeats.
  • Information by UniProt

Human SKP2 peptide (ab26153)参考文献

ab26153 has not yet been referenced specifically in any publications.

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