概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列SRCGELLPLIDPC
    • 氨基酸302 to 314

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SIRT4 antibody (ab10140)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • MGC130046
    • MGC130047
    • MGC57437
    • NAD dependent deacetylase sirtuin 4
    • NAD dependent protein deacetylase sirtuin 4
    • NAD-dependent ADP-ribosyltransferase sirtuin-4
    • NAD-dependent protein deacetylase sirtuin-4
    • NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
    • Regulatory protein SIR2 homolog 4
    • Silent mating type information regulation 2 homolog
    • Sir 2 like 4
    • SIR 2 like protein 4
    • Sir2 like 4
    • SIR2 like protein 4
    • SIR2-like protein 4
    • SIR2L 4
    • SIR2L4
    • SIR4_HUMAN
    • SIRT 4
    • Sirt4
    • Sirtuin (silent mating type information regulation 2 homolog) 4
    • Sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
    • Sirtuin 4
    • Sirtuin type 4
    • Sirtuin-4
    • Sirtuin4
    see all
  • 功能Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner (PubMed:25525879). Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest (PubMed:16959573, PubMed:17715127). In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor (PubMed:23562301, PubMed:23663782). Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis (By similarity). Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1:PPARA interaction probably through the regulation of NAD(+) levels (PubMed:24043310). Down-regulates insulin secretion.
  • 组织特异性Detected in vascular smooth muscle and striated muscle. Detected in insulin-producing beta-cells in pancreas islets of Langerhans (at protein level). Widely expressed. Weakly expressed in leukocytes and fetal thymus.
  • 序列相似性Belongs to the sirtuin family. Class II subfamily.
    Contains 1 deacetylase sirtuin-type domain.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt

Human SIRT4 peptide (ab23185)参考文献

ab23185 has not yet been referenced specifically in any publications.

Product Wall

Thanks again for contacting us with your question, and for your patience. The peptide for ab49173 is now available on our website as ab123888- http://www.abcam.com/SIRT5-peptide-ab123888.html Unfortunately the peptide for ab78977 is not available for s...

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Thank you for contacting us with your question. We do have the blocking peptide for the SIRT5 antibody ab49173, but it isn't on our website at this point so I'm working to have this added. I'll have to check with the lab about the peptide for the SIRT7...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"