功能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
组织特异性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain.
翻译后修饰Phosphorylated on serine and tyrosine residues.
细胞定位Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
All lanes : Anti-SHP1 (phospho Y536) antibody (ab41437)
Lane 3 : human Jurkat cells
treated with pervanadate (1 mM) for 30 min. Lane 4 : human Jurkat cells
treated with pervanadate (1 mM)for 30 min and exposed to alkaline
phosphatase Lane 5 : human Jurkat cells
treated with pervanadate (1 mM) for 30 min. with phospho-SHP1 (Tyr-536)
Human SHP1 peptide (ab42773)参考文献
has not yet been referenced specifically in any publications.