概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 修饰phospho S591

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技术指标

Our Abpromise guarantee covers the use of ab42772 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The ab42772 peptide blocks antibodies that recognise amino acids around phosphorylated serine 591 of human SHP1. This sequence is highly conserved in rat and mouse SHP1.
  • 应用

    Blocking - Blocking peptide for Anti-SHP1 (phospho S591) antibody (ab41436)

    ELISA

  • 形式Liquid
  • 补充说明


    Tyrosine and serine phosphorylation regulate SHP1 activity. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity.

    The ab42772 peptide blocks antibodies that recognise amino acids around phosphorylated serine 591 of human SHP1. This sequence is highly conserved in rat and mouse SHP1.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

常规信息

  • 别名
    • 70Z-SHP
    • EC 3.1.3.48
    • HCP
    • HCPH
    • Hematopoietic cell phosphatase
    • Hematopoietic cell protein tyrosine phosphatase
    • Hematopoietic cell protein-tyrosine phosphatase
    • HPTP1C
    • Protein tyrosine phosphatase 1C
    • Protein tyrosine phosphatase non receptor type 6
    • Protein tyrosine phosphatase SHP1
    • Protein-tyrosine phosphatase 1C
    • protein-tyrosine phosphatase SHP 1
    • Protein-tyrosine phosphatase SHP-1
    • PTN6_HUMAN
    • PTP 1C
    • PTP-1C
    • PTP1C
    • Ptpn6
    • SH PTP 1
    • SH PTP1
    • SH-PTP1
    • SHP 1
    • SHP 1L
    • SHP1
    • SHP1L
    • tyrosine protein phosphatase non receptor type 6
    • Tyrosine-protein phosphatase non-receptor type 6
    see all
  • 功能Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.
  • 组织特异性Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.
  • 序列相似性Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.
    Contains 2 SH2 domains.
    Contains 1 tyrosine-protein phosphatase domain.
  • 翻译后修饰Phosphorylated on serine and tyrosine residues.
  • 细胞定位Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II.
  • Information by UniProt

Human SHP1 peptide 图像

  • All lanes : Anti-SHP1 (phospho S591) antibody (ab41436)

    Lane 3 : human Jurkat cells treated with pervanadate (1 mM) for 30 min
    Lane 4 : human Jurkat cells treated with pervanadate (1 mM ( for 30 min) and exposed to lambda phosphatase
    Lane 5 : human Jurkat cells treated with pervanadate (1 mM) for 30 min with phospho-SHP1 (Ser-591) peptide
    Lane 6 : human Jurkat cells treated with pervanadate (1 mM) for 30 min with non-specific phospho-serine peptide

Human SHP1 peptide (ab42772)参考文献

ab42772 has not yet been referenced specifically in any publications.

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