概述

  • 产品名称人SHB肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EHLSLLYPVAVRTL
    • 氨基酸496 to 509

技术指标

Our Abpromise guarantee covers the use of ab22790 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • bA3J10.2
    • OTTHUMP00000021397
    • RP11 3J10.8
    • RP113J10.8
    • SH2 domain containing adapter protein B
    • SH2 domain-containing adapter protein B
    • Shb
    • SHB (Src homology 2 domain containing) adaptor protein B
    • SHB adaptor protein
    • SHB adaptor protein (a Src homology 2 protein)
    • SHB_HUMAN
    • Src homology 2 domain containing adaptor protein B
    • Src homology 2 protein
    see all
  • 功能Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.
  • 组织特异性Widely expressed.
  • 序列相似性Contains 1 SH2 domain.
  • 结构域The SH2 domain preferentially binds phosphopeptides with the consensus sequence Y-[TVI]-X-L and mediates interaction with PDGFRA, PDGFRB, FGRFR1, IL2RB, IL2RG, CD3Z and CRK/CrKII.
  • 翻译后修饰Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation.
  • 细胞定位Cytoplasm. Cell membrane. Associates with membrane lipid rafts upon TCR stimulation.
  • Information by UniProt

Human SHB peptide (ab22790)参考文献

ab22790 has not yet been referenced specifically in any publications.

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