概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      RWQKCVDCNGSYFD
    • 氨基酸
      658 to 671

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SETMAR antibody (ab3823)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Histone lysine N methyltransferase
    • Histone lysine N methyltransferase SETMAR
    • Hsmar 1
    • Hsmar1
    • Mariner transposase Hsmar1
    • Metnase
    • SET domain and mariner transposase fusion
    • SET domain and mariner transposase fusion gene
    • SET domain and mariner transposase fusion gene containing protein
    • SET domain and mariner transposase fusion gene-containing protein
    • Setmar
    • SETMR_HUMAN
    see all
  • 功能
    Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA.
  • 组织特异性
    Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle.
  • 序列相似性
    In the N-terminal section; belongs to the histone-lysine methyltransferase family.
    In the C-terminal section; belongs to the mariner transposase family.
    Contains 1 post-SET domain.
    Contains 1 pre-SET domain.
    Contains 1 SET domain.
  • 结构域
    The mariner transposase Hsmar1 region mediates DNA-binding. It has no transposase activity because the active site contains an Asn in position 610 instead of a Asp residue.
  • 细胞定位
    Nucleus. Chromosome.
  • Information by UniProt

文献

ab22960 has not yet been referenced specifically in any publications.

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