概述

  • 产品名称人SENP6肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列AAGKSGGSAGEIT-C
    • 氨基酸2 to 14

技术指标

Our Abpromise guarantee covers the use of ab23114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 2810017C20Rik
    • FLJ11355
    • FLJ11887
    • KIAA0389
    • KIAA0797
    • SENP 6
    • Senp6
    • SENP6_HUMAN
    • Sentrin specific protease 6
    • Sentrin-specific protease 6
    • Sentrin/SUMO specific protease SENP6
    • Sentrin/SUMO-specific protease SENP6
    • SSP 1
    • SSP1
    • SUMO 1 specific protease
    • SUMO 1 specific protease 1
    • SUMO-1-specific protease 1
    • SUMO1 specific protease
    • SUMO1 specific protease 1
    • SUMO1/sentrin specific peptidase 6
    • SUSP 1
    • SUSP1
    see all
  • 功能Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombinaison.
  • 组织特异性Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • 通路Protein modification; protein sumoylation.
  • 序列相似性Belongs to the peptidase C48 family.
  • 细胞定位Nucleus.
  • Information by UniProt

Human SENP6 peptide (ab23114)参考文献

ab23114 has not yet been referenced specifically in any publications.

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