概述

  • 产品名称人SCRIBBLE肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-VRPGRRGLGPVPS
    • 氨基酸1618 to 1630

技术指标

Our Abpromise guarantee covers the use of ab23149 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • CRIB 1
    • CRIB1
    • hScrib
    • LAP 4
    • LAP4
    • PDZ domain protein scribble
    • Protein LAP4
    • Protein scribble homolog
    • SCRB 1
    • SCRB1
    • Scrib
    • SCRIB 1
    • SCRIB_HUMAN
    • SCRIB1
    • Scribble
    • Scribble homolog 1
    • scribbled homolog (Drosophila)
    • Vartul
    see all
  • 功能Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.
  • 组织特异性Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).
  • 序列相似性Belongs to the LAP (LRR and PDZ) protein family.
    Contains 16 LRR (leucine-rich) repeats.
    Contains 4 PDZ (DHR) domains.
  • 翻译后修饰Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.
  • 细胞定位Cell membrane. Cell junction > adherens junction. Cytoplasm. Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
  • Information by UniProt

Human SCRIBBLE peptide (ab23149)参考文献

ab23149 has not yet been referenced specifically in any publications.

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