概述

  • 产品名称
    人SARM肽

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab41853 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-SARM antibody (ab17812)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl), pH 7.2

常规信息

  • 别名
    • FLJ36296
    • KIAA0524
    • MyD88-5
    • SAM and ARM-containing protein
    • SAM domain-containing protein 2
    • SAMD2
    • SARM 1
    • SARM1
    • SARM1_HUMAN
    • Sterile alpha and Armadillo repeat protein
    • sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila
    • sterile alpha and HEAT/Armadillo motifs-containing protein
    • sterile alpha and TIR motif containing 1
    • Sterile alpha and TIR motif-containing protein 1
    • Sterile alpha and TIR motifs-containing protein 1
    • Sterile alpha motif domain-containing protein 2
    • Tir-1 homolog
    see all
  • 功能
    Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and IRF activation.
  • 组织特异性
    Predominantly expressed in kidney and liver. Expressed at lower level in placenta.
  • 序列相似性
    Contains 2 SAM (sterile alpha motif) domains.
    Contains 1 TIR domain.
  • 细胞定位
    Cytoplasm.
  • Information by UniProt

文献

ab41853 has not yet been referenced specifically in any publications.

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