人S100A9肽(ab74434)

概述

描述

  • 性质Synthetic

相关产品

技术指标

Our Abpromise guarantee covers the use of ab74434 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 纯度70 - 90% by HPLC.

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Leukocyte L1 complex heavy chain
    • 60B8AG
    • CAGB
    • Calgranulin B
    • Calgranulin-B
    • Calprotectin L1H subunit
    • CFAG
    • CGLB
    • Cystic fibrosis antigen B
    • L1AG
    • Leukocyte L1 complex heavy chain
    • LIAG
    • MAC387
    • MIF
    • Migration inhibitory factor related protein 14
    • Migration inhibitory factor-related protein 14
    • MRP 14
    • MRP-14
    • MRP14
    • Myeloid-related protein 14
    • NIF
    • OTTHUMP00000015331
    • p14
    • Protein S100-A9
    • S100 A9
    • S100 calcium binding protein A9
    • S100 calcium binding protein A9 calgranulin B
    • S100 calcium-binding protein A9
    • S100A9
    • S10A9_HUMAN
    see all
  • 功能Calcium-binding protein. Has antimicrobial activity towards bacteria and fungi. Important for resistance to invasion by pathogenic bacteria. Up-regulates transcription of genes that are under the control of NF-kappa-B. Plays a role in the development of endotoxic shock in response to bacterial lipopolysaccharide (LPS) (By similarity). Promotes tubulin polymerization when unphosphorylated. Promotes phagocyte migration and infiltration of granulocytes at sites of wounding. Plays a role as a pro-inflammatory mediator in acute and chronic inflammation and up-regulates the release of IL8 and cell-surface expression of ICAM1. Extracellular calprotectin binds to target cells and promotes apoptosis. Antimicrobial and proapoptotic activity is inhibited by zinc ions.
  • 组织特异性Expressed by macrophages in acutely inflammed tissues and in chronic inflammation. Detected in peripheral blood leukocytes, in neutrophils and granulocytes. Detected at sites of vascular inflammation (at protein level). Also expressed in epithelial cells constitutively or induced during dermatoses.
  • 序列相似性Belongs to the S-100 family.
    Contains 2 EF-hand domains.
  • 翻译后修饰Phosphorylated. Phosphorylation inhibits activation of tubulin polymerization.
  • 细胞定位Secreted. Cytoplasm. Cytoplasm > cytoskeleton. Cell membrane. Associates with tubulin filaments in activated monocytes. Targeted to the cell surface upon calcium influx. Released from blood leukocytes upon exposure to CSF2/GM-CSF, bacterial lipopolysaccharide (LPS) and during inflammatory processes. Serum levels are high in patients suffering from chronic inflammation.
  • Information by UniProt

Human S100A9 peptide (ab74434)参考文献

ab74434 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

The immunogen for ab50143 is full length S100A9 (113 amino acids). However, the epitope for the antibody is not mapped. Since it is a monoclonal antibody, it can only recognise a single epitope along the full len...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"