概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列KELFTSEFEPAMQIDG
    • 氨基酸541 to 556

相关产品

技术指标

Our Abpromise guarantee covers the use of ab39775 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ROR alpha antibody (ab16367)

    Neutralising

  • 纯度> 90 % SDS-PAGE.
    This antibody is greater than 70% pure.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Double distilled water or equivalent after reconstitution.

常规信息

  • 别名
    • fhl2a
    • NR1F1
    • Nuclear receptor ROR-alpha
    • Nuclear receptor RZR-alpha
    • Nuclear receptor subfamily 1 group F member 1
    • RAR-related orphan receptor A
    • Retinoid-related orphan receptor-alpha
    • Rora
    • RORA_HUMAN
    • RZR-ALPHA
    • RZRA
    see all
  • 功能Orphan nuclear receptor. Binds DNA as a monomer to hormone response elements (HRE) containing a single core motif half-site preceded by a short A-T-rich sequence. This isomer binds to the consensus sequence 5'-[AT][TA]A[AT][CGT]TAGGTCA-3'. Regulates a number of genes involved in lipid metabolism such as apolipoproteins AI, APOA5, CIII, CYP71 and PPARgamma, in cerebellum and photoreceptor development including PCP2, OPN1SW, OPN1SM AND ARR3, in circadian rhythm with BMAL1, and skeletal muscle development with MYOD1. Possible receptor for cholesterol or one of its derivatives.
  • 组织特异性Widely expressed in a number of tissues.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻译后修饰Phosphorylation by PKC in neurons inhibits transcriptional activity. Phosphorylated on Thr-216 by ERK2 in vitro.
    Sumoylated by SENP1 and SENP2. Sumoylation, promoted by PIAS2, PIAS3, PIASy but not PIAS1, enhances the transcriptional activity. Desumoylated by SENP1.
    Ubiquitinated. Ubiquitination is required for efficient transcriptional activity and is prevented by Hairless.
  • 细胞定位Nucleus.
  • Information by UniProt

Human ROR alpha peptide (ab39775)参考文献

ab39775 has not yet been referenced specifically in any publications.

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