- 氨基酸2 to 14
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- E3 ubiquitin-protein ligase Praja 1
- E3 ubiquitin-protein ligase Praja-1
- 功能Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting.
- 组织特异性Expressed in various regions of the brain including the cerebellum, cerebral cortex, medulla, occipital pole, frontal lobe, temporal lobe and putamen. Highest levels in the cerebral cortex.
- 序列相似性Contains 1 RING-type zinc finger.
- 结构域The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
- 翻译后修饰Substrate for E2-dependent ubiquitination.
Information by UniProt
Human RNF70 peptide (ab23047)参考文献
has not yet been referenced specifically in any publications.
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