人RhoA (phospho S188)肽(ab42767)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列This sequence is highly conserved in Rat and Mouse RhoA but is not found in RhoB or RhoC proteins.
    • 修饰phospho S188

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技术指标

Our Abpromise guarantee covers the use of ab42767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-RhoA (phospho S188) antibody (ab41435)

    ELISA

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.05% Sodium Azide
    Constituents: PBS

常规信息

  • 别名
    • Aplysia ras related homolog 12
    • ARH12
    • ARHA
    • H 12
    • H12
    • Oncogene RHO H12
    • Ras homolog family member A
    • Ras homolog gene family member A
    • Rho A
    • Rho cDNA clone 12
    • RHO H12
    • RHO12
    • RHOA
    • RHOA_HUMAN
    • RHOH12
    • Small GTP binding protein Rho A
    • Transforming protein Rho A
    • Transforming protein RhoA
    see all
  • 功能Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP.
  • 序列相似性Belongs to the small GTPase superfamily. Rho family.
  • 结构域The basic-rich region is essential for yopT recognition and cleavage.
  • 翻译后修饰Substrate for botulinum ADP-ribosyltransferase.
    Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
    AMPylation at Tyr-34 and Thr-37 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively. AMPylation occurs in the effector region and leads to inactivation of the GTPase activity by preventing the interaction with downstream effectors, thereby inhibiting actin assembly in infected cells. It is unclear whether some human enzyme mediates AMPylation; FICD has such ability in vitro but additional experiments remain to be done to confirm results in vivo.
    Ubiquitinated by the BCR(BACURD1) and BCR(BACURD2) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration.
  • 细胞定位Cell membrane. Cytoplasm > cytoskeleton.
  • Information by UniProt

Human RhoA (phospho S188) peptide (ab42767)参考文献

ab42767 has not yet been referenced specifically in any publications.

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