概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-NSAQRRLGDSSDL
    • 氨基酸158 to 170

技术指标

Our Abpromise guarantee covers the use of ab23004 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • GRP4_HUMAN
    • Guanyl nucleotide releasing protein 4
    • RAS guanyl releasing protein 4
    • RAS guanyl-releasing protein 4
    • RASGRP4
    see all
  • 功能Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP. May function in mast cells differentiation.
  • 组织特异性Expressed by mast cells and their progenitors (at protein level). Specifically expressed in mononuclear leukocytes. Highly expressed in myeloid cells compared to lymphoid cells. Also detected in heart, skeletal muscle, spleen, liver, placenta and lung. Not detected in brain. Isoform 1 is the major isoform in normal individuals. Isoform 2 is more significantly expressed in a patient with asthma. Isoform 3 is more significantly expressed in a patient with asthma and a mastocytosis patient.
  • 序列相似性Belongs to the RASGRP family.
    Contains 1 EF-hand domain.
    Contains 1 N-terminal Ras-GEF domain.
    Contains 1 phorbol-ester/DAG-type zinc finger.
    Contains 1 Ras-GEF domain.
  • 发展阶段Expressed early during development. Detected in all fetal tissues tested.
  • 结构域The phorbol-ester/DAG-type zinc finger mediates the binding and the functional activation by DAG.
  • 细胞定位Cytoplasm. Cell membrane. Recruited to membranes upon activation by DAG.
  • Information by UniProt

Human RASGRP 4 peptide (ab23004)参考文献

ab23004 has not yet been referenced specifically in any publications.

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