概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

相关产品

技术指标

Our Abpromise guarantee covers the use of ab39860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性This peptide is used for blocking the activity of the Anti-Raptor antibody (ab26264).
  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • KIAA1303
    • KOG1
    • Mip1
    • P150 target of rapamycin (TOR) scaffold protein
    • p150 target of rapamycin (TOR) scaffold protein containing WD repeats
    • P150 target of rapamycin (TOR)-scaffold protein
    • Raptor
    • Regulatory associated protein of mTOR
    • Regulatory associated protein of MTOR complex 1
    • Regulatory-associated protein of mTOR
    • RPTOR
    • RPTOR_HUMAN
    see all
  • 功能Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation.
  • 组织特异性Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta.
  • 序列相似性Belongs to the WD repeat RAPTOR family.
    Contains 7 WD repeats.
  • 细胞定位Cytoplasm. Lysosome. Targeting to lysosomes depends on amino acid availability.
  • Information by UniProt

Human Raptor peptide (ab39860)参考文献

ab39860 has not yet been referenced specifically in any publications.

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