概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列ASEDIAKLAETLAK-C
    • 氨基酸2 to 15

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-RanGAP1 antibody (ab2081)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Fug 1
    • Fug1
    • GTPase-activating protein, RAN, 1
    • KIAA1835
    • MGC20266
    • OTTHUMP00000028918
    • OTTHUMP00000198755
    • OTTHUMP00000198756
    • OTTHUMP00000198757
    • OTTHUMP00000198758
    • RAGP1_HUMAN
    • Ran 1
    • RAN GTPase activating protein 1
    • Ran GTPase-activating protein 1
    • Ran1
    • RANGAP
    • RANGAP 1
    • RanGAP1
    • SD
    • Segregation distorter homolog
    • Segregation distortion
    see all
  • 功能GTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
  • 组织特异性Highly expressed in brain, thymus and testis.
  • 序列相似性Belongs to the RNA1 family.
    Contains 6 LRR (leucine-rich) repeats.
  • 翻译后修饰Phosphorylated occurs before nuclear envelope breakdown and continues throughout mitosis. Phosphorylated by the M-phase kinase cyclin B/Cdk1, in vitro. Differential timimg of dephosphorylation occurs during phases of mitosis. The phosphorylated form remains associated with RANBP2/NUP358 and the SUMO E2-conjugating enzyme, UBC9, on nuclear pore complex (NPC) diassembly and during mitosis.
    Sumoylated with SUMO1. Sumoylation is necessary for targeting to the nuclear envelope (NE), and for association with mitotic spindles and kinetochores during mitosis. Also required for interaction with RANBP2 and is mediated by UBC9.
  • 细胞定位Cytoplasm. Nucleus membrane. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle pole. Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
  • Information by UniProt

Human RanGAP1 peptide (ab22867)参考文献

ab22867 has not yet been referenced specifically in any publications.

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