The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Ran antibody (ab17033)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Androgen receptor associated protein 24
Androgen receptor-associated protein 24
GTP binding nuclear protein RAN
GTP-binding nuclear protein Ran
Guanosine triphosphatase Ran
RAN member RAS oncogene family
Ras like protein TC4
Ras related nuclear protein
Ras-like protein TC4
Ras-related nuclear protein
功能GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Enhances AR-mediated transactivation. Transactivation decreases as the poly-Gln length within AR increases.
组织特异性Expressed in a variety of tissues.
序列相似性Belongs to the small GTPase superfamily. Ran family.
翻译后修饰The N-terminus is blocked.
细胞定位Nucleus. Cytoplasm. Melanosome. Becomes dispersed throughout the cytoplasm during mitosis. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.