- 氨基酸1192 to 1204
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The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- 功能Guanine nucleotide exchange factor (GEF) for Rap1A, Rap2A and M-Ras GTPases. Does not interact with cAMP.
- 组织特异性Isoform 3 has highest expression levels in the brain, heart, liver, lung and placenta and is barely detectable in skeletal muscle, kidney and pancreas.
- 序列相似性Contains 1 cyclic nucleotide-binding domain.
Contains 1 N-terminal Ras-GEF domain.
Contains 1 PDZ (DHR) domain.
Contains 1 Ras-associating domain.
Contains 1 Ras-GEF domain.
- 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
- 细胞定位Cytoplasm. Cell membrane. Upon binding to M-Ras, it translocates to the plasma membrane.
Information by UniProt
Human RAGEF2 peptide (ab23175)参考文献
has not yet been referenced specifically in any publications.
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