人PTHLH多肽(ab42283)
Key features and details
- Purity: > 95% HPLC
- Suitable for: Blocking
描述
-
产品名称
人PTHLH多肽
参阅全部 PTHLH 蛋白酶 -
纯度
> 95 % HPLC. -
无动物成分
No -
性质
Synthetic -
-
种属
Human -
序列
TRSAW -
氨基酸
107 to 111
-
技术指标
Our Abpromise guarantee covers the use of ab42283 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
应用
Blocking
-
形式
Lyophilized -
Concentration information loading...
制备和贮存
-
稳定性和存储
Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.
Constituent: 0.1% Acetic acid
-
复溶Store at 2 to -8°C lyophilised, resuspend in 0.1% actetic acid
常规信息
-
别名
- HHM
- MGC14611
- Osteostatin
see all -
功能
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1-dependent manner through activation of Rac1.
Osteostatin is a potent inhibitor of osteoclastic bone resorption. -
组织特异性
Ubiquitous. Also expressed in the mammary gland. -
疾病相关
Brachydactyly E2 -
序列相似性
Belongs to the parathyroid hormone family. -
翻译后修饰
There are 3 principal secretory forms, called PTHrP[1-36], PTHrP[38-94], and osteostatin (PTHrP[107-139]) arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. -
细胞定位
Cytoplasm. Nucleus. Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
Datasheet download
文献 (0)
ab42283 尚未被引用在任何文献中。