概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-LKVKGEKSGLMST
    • 氨基酸
      487 to 499

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22909 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PRPF31 antibody (ab2467)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • DKFZp566J153
    • hPrp 31
    • hPrp31
    • NY BR 99
    • Pre mRNA processing factor 31
    • Pre mRNA processing factor 31 homolog
    • Pre mRNA processing factor 31 homolog (yeast)
    • Pre-mRNA-processing factor 31
    • Precursor mRNA-processing factor 31, S. cerevisiae, homolog of
    • Protein 61K
    • PRP 31
    • PRP31
    • PRP31 pre mRNA processing factor 31 homolog
    • PRP31 pre mRNA processing factor 31 homolog (yeast)
    • PRP31_HUMAN
    • PRPF 31
    • prpf31
    • RP 11
    • RP11
    • Serologically defined breast cancer antigen NY BR 99
    • Serologically defined breast cancer antigen NY-BR-99
    • SNRNP61
    • U4/U6 small nuclear ribonucleoprotein Prp31
    • U4/U6 snRNP 61 kDa protein
    see all
  • 功能
    Involved in pre-mRNA splicing. Required for U4/U6.U5 tri-snRNP formation.
  • 组织特异性
    Ubiquitously expressed.
  • 疾病相关
    Defects in PRPF31 are the cause of retinitis pigmentosa type 11 (RP11) [MIM:600138]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP11 inheritance is autosomal dominant.
  • 序列相似性
    Belongs to the PRP31 family.
    Contains 1 Nop domain.
  • 结构域
    Interacts with the snRNP via the Nop domain.
    The coiled coil domain is formed by two non-contiguous helices.
  • 细胞定位
    Nucleus speckle. Nucleus > Cajal body. Predominantly found in speckles and in Cajal bodies.
  • Information by UniProt

Human PRPF31 peptide (ab22909)参考文献

ab22909 has not yet been referenced specifically in any publications.

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