概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionP25786
    • 种属Human
    • 序列PADEPAEKADEPMEH
    • 氨基酸249 to 263

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技术指标

Our Abpromise guarantee covers the use of ab4943 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S C2 subunit, catalog ab3325. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

常规信息

  • 别名
    • 30 kDa prosomal protein
    • HC 2
    • HC2
    • Macropain subunit C2
    • Macropain subunit nu
    • MGC14542
    • MGC14575
    • MGC14751
    • MGC1667
    • MGC21459
    • MGC22853
    • MGC23915
    • Multicatalytic endopeptidase complex subunit C2
    • NU
    • PROS 30
    • PROS-30
    • PROS30
    • Proteasome (prosome macropain) subunit alpha type 1
    • Proteasome alpha 1 subunit
    • Proteasome component C2
    • Proteasome nu chain
    • Proteasome subunit alpha type 1
    • Proteasome subunit alpha type I
    • Proteasome subunit alpha type-1
    • Proteasome subunit nu
    • Protein P30 33K
    • PSA1_HUMAN
    • PSC 2
    • PSC2
    • PSMA 1
    • psmA1
    see all
  • 功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells.
  • 序列相似性Belongs to the peptidase T1A family.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt

Human Proteasome 20S C2 peptide (ab4943)参考文献

This product has been referenced in:
  • Chu Y  et al. Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol Dis 35:385-98 (2009). Read more (PubMed: 19505575) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"