序列An 18 amino acid synthetic peptide whose sequence is derived from human proteasome 20S beta 6 and amino acid residues 74-91 from frog protein. The sequence of this peptide is (amino to carboxy terminus): C(41)RSGSAADTQAV/IADAVTY(58).
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human proteasome 20S beta 6, catalog ab3331. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Macropain delta chain
Multicatalytic endopeptidase complex delta chain
Proteasome (prosome macropain) subunit beta type 6
Proteasome beta 6 subunit
Proteasome catalytic subunit 1
Proteasome delta chain
Proteasome subunit beta 6
Proteasome subunit beta type 6
Proteasome subunit beta type-6
Proteasome subunit delta
Proteasome subunit Y
PSY large multifunctional protease Y
功能The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the peptidyl glutamyl-like activity. May catalyze basal processing of intracellular antigens.
Wang Y et al. Proteomic Analysis Implicates Dominant Alterations of RNA Metabolism and the Proteasome Pathway in the Cellular Response to Carbon-Ion Irradiation. PLoS One11:e0163896 (2016).
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