人Prostate Specific Antigen ELISA试剂盒(f-PSA) (ab108656)

概述

  • 产品名称人Prostate Specific Antigen ELISA试剂盒(f-PSA)
    参阅全部 Prostate Specific Antigen 试剂盒
  • 检测方法Colorimetric
  • 测试
    1 x 96 well plate
  • 样品类型
    Serum
  • 检测类型Sandwich (quantitative)
  • 灵敏度
    = 0.1 ng/ml
  • 范围
    0.1 ng/ml - 25 ng/ml
  • 实验步骤Multiple steps standard assay
  • 种属反应性
    与反应: Human
  • 产品概述

    For quantification down to 4.8 pg/mL in a 90 minute, no-wash ELISA assay, try Human Free Prostate Specific Antigen ELISA kit SimpleStep (ab188389).


    ab108656 is intended for the quantitative determination of the cancer antigen Prostate Specific Antigen (f-PSA) concentration in Human serum.


    Human Prostate Specific Antigen is a 33 kD serineproteinase which, in Human serum, is predominantly bound to alpha 1-antichymotrypsin (PSA-ACT) and alpha 2-macroglobulin (PSA-AMG). Trace amounts of alpha 1-antitrypsin and inter-alpha trypsin inhibitor bound to PSA can also be found. Any remaining PSA is in the free form (f-PSA). Current methods of screening men for prostate cancer utilize the detection of the major PSA-ACT form. Levels of 4.0 ng/ml or higher are strong indicators of the possibility of prostatic cancer. However, elevated serum PSA levels have also been attributed to benign prostatic hyperplasia and prostatitis, leading to a large percentage of false positive screening results. A potential solution to this problem involves the determination of free PSA levels. Preliminary studies have suggested that the percentage of free PSA is lower in patients with prostate cancer than those with benign prostatic hyperplasia. Thus, the measurement of free serum PSA in conjunction with total PSA, can improve specificity of prostate cancer screening in selected men with elevated total serum PSA levels, which would subsequently reduce unnecessary prostate biopsies with minimal effects on cancer detection rates.

  • 经测试应用适用于: Sandwich ELISAmore details
  • 平台Microplate

性能

  • 功能Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum.
  • 序列相似性Belongs to the peptidase S1 family. Kallikrein subfamily.
    Contains 1 peptidase S1 domain.
  • 细胞定位Secreted.
  • Information by UniProt
  • 别名
    • antigen, prostate-specific
    • APS
    • Gamma seminoprotein
    • Gamma-seminoprotein
    • hK3
    • Kallikrein 3
    • Kallikrein related peptidase 3
    • Kallikrein-3
    • KLK 3
    • KLK2A1
    • Klk3
    • KLK3_HUMAN
    • P-30 antigen
    • P30 antigen
    • Prostate-specific antigen
    • Psa
    • Semenogelase
    • Seminin
    see all
  • 数据库链接

应用

Our Abpromise guarantee covers the use of ab108656 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Sandwich ELISA Use at an assay dependent dilution.

Human Prostate Specific Antigen ELISA Kit (f-PSA) 图像

  • Human Prostate Specific Antigen (f-PSA) Standard Curve

实验方案

Human Prostate Specific Antigen ELISA Kit (f-PSA) (ab108656)参考文献

ab108656 has not yet been referenced specifically in any publications.

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