概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-ERDGSGTNKRDKQYQ
    • 氨基酸84 to 98

相关产品

技术指标

Our Abpromise guarantee covers the use of ab48048 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PRODH antibody (ab48001)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • HSPOX2
    • mitochondrial
    • P53 induced gene 6 protein
    • p53-induced gene 6 protein
    • PIG6
    • POX
    • PROD_HUMAN
    • PRODH
    • PRODH 1
    • PRODH 2
    • PRODH1
    • PRODH2
    • Proline dehydrogenase
    • proline dehydrogenase (oxidase) 1
    • proline dehydrogenase (proline oxidase)
    • Proline dehydrogenase 1
    • Proline dehydrogenase 1, mitochondrial
    • Proline oxidase
    • Proline oxidase 1
    • Proline oxidase 2
    • Proline oxidase, mitochondrial
    • Proline oxidase, mitochondrial precursor
    • SCZD4
    • TP53I6
    • tumor protein p53 inducible protein 6
    see all
  • 功能Converts proline to delta-1-pyrroline-5-carboxylate.
  • 组织特异性Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
  • 通路Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
  • 疾病相关Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome.
    Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • 序列相似性Belongs to the proline oxidase family.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt

Human PRODH peptide (ab48048)参考文献

ab48048 has not yet been referenced specifically in any publications.

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