The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-PRODH antibody (ab48001)
Concentration information loading...
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
P53 induced gene 6 protein
p53-induced gene 6 protein
proline dehydrogenase (oxidase) 1
proline dehydrogenase (proline oxidase)
Proline dehydrogenase 1
Proline dehydrogenase 1, mitochondrial
Proline oxidase 1
Proline oxidase 2
Proline oxidase, mitochondrial
Proline oxidase, mitochondrial precursor
tumor protein p53 inducible protein 6
功能Converts proline to delta-1-pyrroline-5-carboxylate.
组织特异性Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
通路Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
疾病相关Defects in PRODH are the cause of hyperprolinemia type 1 (HP-1) [MIM:239500]. HP-1 is a disorder characterized by elevated serum proline levels. May be involved in the psychiatric and behavioral phenotypes associated with the 22q11 velocardiofacial and DiGeorge syndrome. Defects in PRODH are associated with susceptibility to schizophrenia type 4 (SCZD4) [MIM:600850]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.