人PP2A alpha + beta肽(ab22802)

概述

  • 产品名称人PP2A alpha + beta肽

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-EPHVTRRTPDYFL
    • 氨基酸297 to 309

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22802 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PP2A alpha + beta antibody (ab1309)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • PP2A A
    • PP2A alpha
    • PP2A B
    • PP2A beta
    • PP2A-alpha
    • PP2AA_HUMAN
    • PP2Ac
    • PP2CB
    • PPP2CA
    • PPP2CB
    • Protein phosphatase 2 catalytic subunit alpha isoform
    • Protein phosphatase 2 catalytic subunit beta isoform
    • Replication protein C
    • RP C
    • RP-C
    • Serine/threonine protein phosphatase 2A catalytic subunit alpha isoform
    • Serine/threonine protein phosphatase 2A catalytic subunit beta isoform
    • Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    see all
  • 功能PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at 'Ser-259'.
  • 序列相似性Belongs to the PPP phosphatase family. PP-1 subfamily.
  • 翻译后修饰Reversibly methyl esterified on Leu-309. Carboxyl methylation may play a role in holoenzyme assembly, enhancing the affinity of the PP2A core enzyme for some, but not all, regulatory subunits. It varies during the cell cycle.
    Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • 细胞定位Cytoplasm. Nucleus. Chromosome > centromere. Cytoplasm > cytoskeleton > spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGOL2.
  • Information by UniProt

Human PP2A alpha + beta peptide (ab22802)参考文献

ab22802 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"