概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列EPRLGRLYCQFSEG
    • 氨基酸508 to 521

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PNK antibody (ab3817)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 2''(3'')-polynucleotidase
    • 2'(3')-polynucleotidase
    • Bifunctional polynucleotide phosphatase/kinase
    • DEM 1
    • DEM1
    • DNA 5' kinase/3' phosphatase
    • DNA 5''-kinase/3''-phosphatase
    • EIEE10
    • Homo sapiens polynucleotide kinase 3' phosphatase (PNKP)
    • MCSZ
    • PNK 1
    • PNK1
    • Pnkp
    • PNKP DNA kinase
    • PNKP_HUMAN
    • Polynucleotide 3'-phosphatase
    • Polynucleotide 5' hydroxyl kinase
    • Polynucleotide 5''-hydroxyl-kinase
    • Polynucleotide Kinase
    • Polynucleotide kinase 3 prime phosphatase
    • Polynucleotide kinase 3' phosphatase
    • Polynucleotide kinase-3''-phosphatase
    see all
  • 功能Catalyzes the phosphorylation of DNA at 5'-hydroxyl termini and can dephosphorylate its 3'-phosphate termini. Plays an important function in DNA repair following ionizing radiation or oxidative damage.
  • 组织特异性Expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine (PubMed:10446192). Expressed in higher amount in pancreas, heart and kidney and at lower levels in brain, lung and liver (PubMed:10446193).
  • 疾病相关Defects in PNKP are the cause of microcephaly seizures and development delay (MCSZ) [MIM:613402]. It is characterized by microcephaly, infantile-onset seizures, severe intellectual disability and delayed motor milestones with absent speech or only achieving a few words. Most patients also have behavioral problems with hyperactivity. Microcephaly is progressive and without neuronal migration or structural abnormalities, consistent with primary microcephaly.
  • 序列相似性In the N-terminal section; belongs to the DNA 3' phosphatase family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt

Human PNK peptide (ab22956)参考文献

ab22956 has not yet been referenced specifically in any publications.

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