概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列ATCIGEKIEDFKVGN
    • 氨基酸2 to 16

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技术指标

Our Abpromise guarantee covers the use of ab22924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PLK4 antibody (ab2642)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • PLK 4
    • PLK-4
    • PLK4
    • PLK4_HUMAN
    • Polo like Kinase 4
    • Polo-like kinase 4
    • Protein serine/threonine kinase
    • SAK
    • Serine/threonine kinase
    • Serine/Threonine Kinase 18
    • Serine/threonine protein kinase 18
    • Serine/threonine protein kinase PLK4
    • Serine/threonine protein kinase Sak
    • Serine/threonine-protein kinase 18
    • Serine/threonine-protein kinase PLK4
    • Serine/threonine-protein kinase SAK
    • Snk Akin Kinase
    • STK 18
    • STK18
    see all
  • 功能Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.
    Contains 1 POLO box domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Ubiquitinated; leading to its degradation by the proteasome.
    Tyrosine-phosphorylated by TEC.
  • 细胞定位Cytoplasm > cytoskeleton > centrosome > centriole. Nucleus > nucleolus. Cleavage furrow. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
  • Information by UniProt

Human PLK4 peptide (ab22924)参考文献

ab22924 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"