概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab51484 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PKR antibody (ab45427)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • Double stranded RNA activated protein kinase;
    • E2AK2_HUMAN
    • eIF-2A protein kinase 2
    • EIF2AK1
    • EIF2AK2
    • Eukaryotic translation initiation factor 2 alpha kinase 2
    • Eukaryotic translation initiation factor 2-alpha kinase 2
    • HGNC:9437
    • Interferon induced double stranded RNA activated protein kinase
    • Interferon inducible elF2 alpha kinase
    • Interferon inducible RNA dependent protein kinase
    • Interferon-induced, double-stranded RNA-activated protein kinase
    • Interferon-inducible RNA-dependent protein kinase
    • MGC126524
    • P1/eIF-2A protein kinase
    • P1/eIF2A protein kinase
    • p68 kinase
    • PKR
    • PPP1R83
    • PRKR
    • Protein kinase interferon inducible double stranded RNA dependent
    • Protein kinase RNA activated
    • Protein kinase RNA-activated
    • Protein phosphatase 1 regulatory subunit 83
    • Serine/threonine protein kinase TIK
    • Tyrosine protein kinase EIF2AK2
    see all
  • 功能Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.
    Contains 2 DRBM (double-stranded RNA-binding) domains.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated on several Ser and Thr residues. Autophosphorylation of Thr-451 is dependent on Thr-446 and is stimulated by dsRNA binding and dimerization. Autophosphorylation apparently leads to the activation of the kinase.
  • Information by UniProt

Human PKR peptide (ab51484)参考文献

ab51484 has not yet been referenced specifically in any publications.

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