概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab39848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PIST antibody (ab37036)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • CAL
    • CFTR associated ligand
    • CFTR-associated ligand
    • dJ94G16.2
    • dJ94G16.2 PIST
    • FIG
    • Fused in glioblastoma
    • Golgi associated PDZ and coiled coil motif containing
    • Golgi associated PDZ and coiled coil motif containing protein
    • Golgi-associated PDZ and coiled-coil motif-containing protein
    • GOPC
    • GOPC 1
    • GOPC_HUMAN
    • GOPC1
    • OTTHUMP00000040403
    • PDZ protein interacting specifically with TC 10
    • PDZ protein interacting specifically with TC10
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC 10
    • PDZ/coiled coil domain binding partner for the rho family GTPase TC10
    • PIST
    • Protein interacting specifically with Tc 10
    • Protein interacting specifically with Tc10
    see all
  • 功能Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ACCN3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes.
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.
  • 序列相似性Contains 1 PDZ (DHR) domain.
  • 结构域The PDZ domain mediates interactions with FZD5, FZD8, ACCN3, GRID2, CLCN3 (By similarity). Mediates also interaction with CFTR and ADRB1.
    The coiled-coil region probably mediates association to membranes, targeting to the Golgi, and interactions with GOLGA3, and STX6. May also mediate interaction with RHOQ.
  • 细胞定位Cytoplasm. Golgi apparatus membrane. Golgi apparatus > trans-Golgi network membrane. Cell junction > synapse. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Enriched in synaptosomal and postsynaptic densities (PSD) fractions (By similarity). Expressed in cell bodies and dendrites of Purkinje cells (By similarity). Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
  • Information by UniProt

Human PIST peptide (ab39848)参考文献

ab39848 has not yet been referenced specifically in any publications.

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