概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      SMLAERRRKQKWAV-C
    • 氨基酸
      2 to 15

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PINX1 antibody (ab2344)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 67-11-3 protein
    • FLJ20565
    • Hepatocellular carcinoma-related putative tumor suppressor
    • Liver-related putative tumor suppressor
    • LPTL
    • LPTS
    • MGC8850
    • OTTHUMP00000224984
    • OTTHUMP00000224985
    • OTTHUMP00000224986
    • OTTHUMP00000225053
    • OTTHUMP00000225054
    • PIN2 interacting protein 1
    • Pin2-interacting protein X1
    • PIN2/TERF1-interacting telomerase inhibitor 1
    • PINX1
    • PINX1_HUMAN
    • Protein 67-11-3
    • TRF1-interacting protein 1
    see all
  • 功能
    Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
  • 组织特异性
    Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
  • 序列相似性
    Belongs to the PINX1 family.
    Contains 1 G-patch domain.
  • 结构域
    The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.
    The TBM domain mediates interaction with TERF1.
  • 细胞定位
    Nucleus. Nucleus > nucleolus. Chromosome > telomere. Chromosome > centromere > kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
  • Information by UniProt

Human PINX1 peptide (ab22903)参考文献

ab22903 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22903.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册