概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      LVRALLQREA SKRPSARVAA N
    • 氨基酸
      484 to 504

相关产品

技术指标

Our Abpromise guarantee covers the use of ab30903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PINK1 antibody (ab23707)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, 200ul Tris buffered saline. pH 7.4

常规信息

  • 别名
    • BRPK
    • FLJ27236
    • mitochondrial
    • PARK 6
    • PARK6
    • Phosphatase and Tensin Homolog
    • PINK 1
    • PINK1
    • PINK1_HUMAN
    • Protein kinase BRPK
    • PTEN induced putative kinase 1
    • PTEN induced putative kinase protein 1
    • PTEN-induced putative kinase protein 1
    • Serine/threonine kinase PINK1 mitochondrial
    • Serine/threonine protein kinase PINK1 mitochondrial
    • Serine/threonine-protein kinase PINK1
    see all
  • 功能
    Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
  • 组织特异性
    Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
  • 疾病相关
    Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
  • 序列相似性
    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻译后修饰
    Autophosphorylated.
  • 细胞定位
    Mitochondrion outer membrane. Cytoplasm > cytosol.
  • Information by UniProt

Human PINK1 peptide (ab30903)参考文献

ab30903 has not yet been referenced specifically in any publications.

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