概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列LVRALLQREA SKRPSARVAA N
    • 氨基酸484 to 504

相关产品

技术指标

Our Abpromise guarantee covers the use of ab30903 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PINK1 antibody (ab23707)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, 200ul Tris buffered saline. pH 7.4

常规信息

  • 别名
    • BRPK
    • FLJ27236
    • mitochondrial
    • PARK 6
    • PARK6
    • Phosphatase and Tensin Homolog
    • PINK 1
    • PINK1
    • PINK1_HUMAN
    • Protein kinase BRPK
    • PTEN induced putative kinase 1
    • PTEN induced putative kinase protein 1
    • PTEN-induced putative kinase protein 1
    • Serine/threonine kinase PINK1 mitochondrial
    • Serine/threonine protein kinase PINK1 mitochondrial
    • Serine/threonine-protein kinase PINK1
    see all
  • 功能Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitement to dysfunctional mitochondria to initiate their degradation.
  • 组织特异性Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
  • 疾病相关Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6) [MIM:605909]. A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated.
  • 细胞定位Mitochondrion outer membrane. Cytoplasm > cytosol.
  • Information by UniProt

Human PINK1 peptide (ab30903)参考文献

ab30903 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab30903.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"