概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab119168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 纯度70 - 90% by HPLC.

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Androgen receptor interacting protein 3
    • Androgen receptor-interacting protein 3
    • ARIP3
    • DAB2 interacting protein
    • DAB2-interacting protein
    • DIP
    • E3 SUMO protein ligase PIAS2
    • E3 SUMO-protein ligase PIAS2
    • MIZ
    • Miz1
    • Msx interacting zinc finger protein
    • Msx-interacting zinc finger protein
    • PIAS NY protein
    • PIAS-NY protein
    • PIAS2
    • PIAS2_HUMAN
    • PIASX
    • PIASX-ALPHA
    • PIASX-BETA
    • Protein inhibitor of activated STAT x
    • Protein inhibitor of activated STAT, 2
    • Protein inhibitor of activated STAT2
    • SIZ2
    • Zinc finger, MIZ-type containing 4
    • ZMIZ4
    see all
  • 功能Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'.
  • 组织特异性Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.
  • 通路Protein modification; protein sumoylation.
  • 序列相似性Belongs to the PIAS family.
    Contains 1 PINIT domain.
    Contains 1 SAP domain.
    Contains 1 SP-RING-type zinc finger.
  • 发展阶段Isoform 3 expression in adult testis is 14.2-fold stronger than in embryonic testis.
  • 结构域The LXXLL motif is a transcriptional coregulator signature.
  • 翻译后修饰Sumoylated.
  • 细胞定位Nucleus speckle. Nucleus, PML body. Nucleus. Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity).
  • Information by UniProt

Human PIAS2 peptide (ab119168)参考文献

ab119168 has not yet been referenced specifically in any publications.

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