概述

描述

  • 性质Synthetic
  • 氨基酸序列

技术指标

Our Abpromise guarantee covers the use of ab73600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-PGC1 alpha + beta antibody (ab72230)

  • 纯度70 - 90% by HPLC.

  • 形式Liquid
  • 补充说明

    This product can used as blocking peptide for ab72230.

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • L PGC 1alpha
    • LEM6
    • Ligand effect modulator 6
    • Peroxisome proliferative activated receptor gamma coactivator 1
    • Peroxisome proliferative activated receptor gamma coactivator 1 alpha
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 3ext
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B4 8a
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5
    • Peroxisome proliferator activated receptor gamma coactivator 1 alpha transcript variant B5 NT
    • Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
    • PGC 1 (alpha)
    • PGC 1 alpha
    • PGC 1v
    • PGC-1-alpha
    • PGC1
    • PGC1(alpha)
    • PGC1A
    • PGC1v
    • PPAR gamma coactivator 1
    • PPAR gamma coactivator 1 alpha
    • PPAR gamma coactivator 1 alpha 3 ligand effect modulator 6
    • PPAR gamma coactivator variant form
    • PPAR-gamma coactivator 1-alpha
    • PPARGC 1 alpha
    • PPARGC-1-alpha
    • PPARGC1
    • PPARGC1A
    • PRGC1_HUMAN
    see all
  • 功能Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK.
  • 组织特异性Heart, skeletal muscle, liver and kidney. Expressed at lower levels in brain and pancreas and at very low levels in the intestine and white adipose tissue. In skeletal muscle, levels were lower in obese than in lean subjects and fasting induced a 2-fold increase in levels in the skeletal muscle in obese subjects.
  • 序列相似性Contains 1 RRM (RNA recognition motif) domain.
  • 翻译后修饰Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2.
    Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions.
    Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation.
  • 细胞定位Cytoplasm. Nucleus; Nucleus and Nucleus. Nucleus, PML body.
  • Information by UniProt

Human PGC1 alpha peptide (ab73600)参考文献

ab73600 has not yet been referenced specifically in any publications.

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