功能Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
组织特异性Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts.
序列相似性Belongs to the TMEM47 family.
细胞定位Cell junction > desmosome. Cell membrane. Associated with desmosomes.