人PDPK1 (unmodified )肽(ab13756)

概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab13756 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • 3 phosphoinositide dependent protein kinase 1
    • 3-phosphoinositide-dependent protein kinase 1
    • hPDK 1
    • hPDK1
    • MGC20087
    • MGC35290
    • OTTHUMP00000159109
    • OTTHUMP00000159110
    • OTTHUMP00000174525
    • PDK1
    • Pdpk1
    • PDPK1_HUMAN
    • PDPK2
    • PkB kinase
    • PkB kinase like gene 1
    • PkB like 1
    • PRO0461
    • Protein kinase
    see all
  • 功能Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.
  • 组织特异性Appears to be expressed ubiquitously.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
  • 翻译后修饰Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.
  • 细胞定位Cytoplasm. Membrane. Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.
  • Information by UniProt

Human PDPK1 (unmodified ) peptide (ab13756)参考文献

ab13756 has not yet been referenced specifically in any publications.

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